Tuberculosis and deaths caused by its infection is major problem in Indonesia. This study was done to describe the association between socio economic factors and tuberculosis’ knowledge. Thedesign of this study was cross-sectional survey. Research subjects were 2419 housewives from11 most populated districts within East-Jakarta selected at random by using polygonal randomsampling. Result showed that 335 respondents (14%) answered correct all question regardingetiology, curability, transmission and length of treatment. Chi-square test showed that tuberculosis’knowledge was significantly associated with level of formal education, employment status, monthlyincome level, and information source. Better knowledge of tuberculosis was significantly related withunemployment (p 0,004 PR 0,894 CI95% 0,83;0,97), high level of monthly income (p < 0,001 PR 1,33CI95% 1,12;1,15), high level of formal education (p < 0,001 PR 1,41 CI95% 1,31; 1,51) and receivinginformation about TB (p < 0,001 PR 0,082 CI95% 0,037; 0,178). Overall, level of tuberculosisknowledge without misconception on housewives within East Jakarta is low. Level of tuberculosisknowledge related to socioeconomic status and can be improved by effective source of information.